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Features Include
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| Garcinia cambodia extract: |
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Influences appetite and energy levels naturally by redirecting calories from fat production towards increasing glycogen production and storage. In addition, its active component, (-) Hydroxy Citric Acid, inhibits the pathway of fatty acid biosynthesis and promotes healthy blood lipid levels.*
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| Chromium polynicotinate: |
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Enhances the effectiveness of (-) Hydroxy Citric Acid by inhibiting the synthesis of new fat from carbohydrates. This form of chromium is prebound to niacin (B3), which is important for enzyme activation and acts as the Glucose Tolerance Factor (GTF) and helps to maintain healthy glucose metabolism and supporting body composition.*
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| Gymnema sylvestre extract: |
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Supports pancreas function and healthy glucose metabolism. Supportive of enzyme activity for glucose utilization, and helps moderate glucose uptake into the intestines. Gymnema also has the potential to support healthy lipid and triglyceride metabolism.*
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| Cinnamon cassia extract: |
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Concentrated cinnamon provides statistically significant support for healthy lipid and triglyceride metabolism. Studies also indicate that the numerous water-soluble polyphenol polymers found naturally in cinnamon may support healthy blood flow and provide antioxidant protection. Its gentle warming properties serve as a mild thermogenic which slightly increases basal body temperature.*
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| 7-Keto DHEA: |
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A safe and natural metabolite of DHEA known as DHEA-Acetate-7-one or 3-acetoxy-androst-5-ene-7,17-dione; a form of DHEA that does not convert to estrogen or testosterone. 7-KETO is several times more potent than DHEA in stimulating the thermogenic enzymes of the liver, promotes basal metabolism, and helps to increase the lean/ adipose ratio.*
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| Lipase: |
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A water-soluble enzyme that catalyzes the hydrolysis of ester bonds of fats into water-insoluble, lipid substrates.*
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Recommendations
Helion Nutraceuticals recommends (for adults):
9 capusules daily in divided doses; 3 capsules, 3 times a day, 30 to 60 minutes before meals.
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Three vegetable capsules contain:
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Garcinia cambogia extract
(standardized to contain 60% (-) hydroxycitric acid) |
1500 mg |
Gymnema sylvestre extract
(standardized to contain 75% gymnemic acids) |
133 mg |
| Cinnamon (cinnamomi cassia) extract (20:1) |
83 mg |
| Chromium polynicotinate |
333 mcg |
| 7-Keto DHEA |
67 mg |
| Lipase |
300 FIP |
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References
1Nageswara Rao R, Sakariah KK. Lipid-lowering and antiobesity effect of (-) hydroxycitric acid. Nutrition Research, Vol. 8, 1998 209-212.
2Sullivan C, Triscari J. Influence of (-)hydroxycitrate on experimentally induced obesity in the rodent. I. Metabolic regulation as a control for lipid disorders. Am J Clin Nutr. 1977 May;30(5):767-776.
3Sullivan A, Triscari J, Hamilton J, Miller O. Effect of (-) hydroxycitrate upon the accumulation of lipid in the rat. Lipids 1973, Vol. 9, No. 2 129-134.
4Sullivan AC, Triscari J, Spiegel JE. Influence of (-) hydroxycitrate on genetically and experimentally induced hypertriglyceridemia in the rat. II. Metabolic regulation as a control of lipid disorders. Am J Clin Nutr 1977 May;30(5):777-784.
5Berkhout TA, Havekas LM, Pearce NJ, Groot PH. The effect of (-)hydroxycitrate on the activity of the low-density-lipoprotien receptor and 3-line Hep G2, Biochem J 1990 Nov 15; 272(1):181-186.
6McCarty MF. Inhibition of citrate lyase may aid aerobic endurance. Med Hypotheses 1995 Sep 45(3):247-254.
7Shanmugasundaram ER, Rajeswari G, Baskaran K, Rajesh Kumar BR, Radha Shanumgasundaram K, Kizar Ahmath B. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990 Oct;30(3):281-94.
8Basharan K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990 Oct;30(3):295-300.
9Crawford V, Scheckenbach R, Preuss HG. Effects of niacin-bound chromium supplementation on body composition in overweight African-American women. Diabetes Obes Metab 1999 Nov;1(6):331-7.
10Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Cinnamon Estract Prevents the Insulin Resistance Induced by a High-Fructose Diet. Horm Metab Res. 2004 Feb; 36(2):119-25.
11Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats. Diabetes Res Clin Pract. 2003 Dec;62(3):139-48.
12Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ. Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem. 2004 Jan 14;52(1):65-70.
13Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003 Dec;26(12):3215-8.
14Broadhurst CL, Polansky MM, Anderson RA. Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. J Agric Food Chem. 2000 Mar;48(3):849-52.
15Imparl-Radosevich J, Deas S, Polansky MM, Baedke DA, Ingebritsen TS, Anderson RA, Graves DJ. Regulation of PTP-1 and insulin receptor kinase by fractions of cinnamon: implications for cinnamon regulation of insulin signaling. Horm Res. 1998 Sep;50(3):177-82.
16Lee JS, Jeon SM, Park EM, Huh TL, Kwon OS, Lee MK, Choi MS. Cinnamon supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats. J Med Food. 2003 Fall;6(3):183-91.
17Lardy H, et al. Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone. Proc Natl Acad Sci USA 1995 Jul 3; 92(14):6617-9.
18Clinical Safety and Endocrine Effects of 7-Keto DHEA. Presentaed at Experimental Biology 1998, April 19-22, San Franciso, CA.
19Lardy H, et al. Ergosteroids II: Biologically active metabolites and synthetic derivatives of dehyroepiandrosterone. Steroids 1998 Mar;63(3):158-65.
20Bobyleva V et al. The effects of the ergosteroid 7-Keto DHEA on mitochondrial membrane potential: possible relationship to thermogenesis. Archives of Biochemistry and Biophysics, Vol. 341, No. 1, pp 122-128, 1997.
21Carlon M et al. Double-Blind Study Evaluating the Effects of Exercise Plus 3-acetyl-7-oxo-dehydroepiandrosterone on Body Composition and the Endocrine System in Overweight Adults. Journal of Exercise Physiology online Vol. 2 No. 4, 1999.
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