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Features Include |
| Alpha Lipoic Acid: |
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Supports healthy liver function by scavenging free radicals and promoting the synthesis, regeneration,
and concentration of glutathione in the liver. Studies also reveal the potential for alpha lipoic acid to facilitate
the biliary excretion of inorganic mercury as well as to moderate lead and cadmium induced oxidative stress.*
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| N-Acetly-Cysteine (NAC): |
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Provides free radical scavenger and additional glutathione-boosting properties. Several studies suggest
that NAC administration to animals may help to reduce mercury and cadmium accumulation in the kidneys
and liver, and/or moderate the effects of these metals in these tissues. NAC may achieve these actions, in part,
by facilitating mercury removal from tissues, promoting healthy glutathione levels, or protecting tissues
from peroxidation generated by heavy metals.*
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| Glycine: |
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Supplementation with glycine has been shown to support healthy kidney and liver function, as well as
nervous system health. Animal studies suggest that glycine plays a protective role for the kidneys and liver,
particularly by supporting detoxification of certain chemicals. Glycine has also been shown to moderate
the release of cytokines during times of metabolic stress.*
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| Magnesium glycinate: |
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Highly absorbable magnesium chelate for sensitive individuals; assists the uptake and utilization of calcium,
synergizes the secretion of parathyroid hormone, and is a vital nutrient cofactor in detoxification pathways.*
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| Malic Acid: |
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Serves as a substrate for energy release from the Krebs cycle (a physiological process in the body that metabolizes
fats and sugars), and aids in promotion and excretion of bile.*
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| Calcium D-glucarate: |
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A patented form of glucaric acid, calcium d-glucarate is a robust nutrient with the potential to support
the body's natural ability to detoxify endogenous and environmental compounds and to promote cellular health
for tissues including the liver, prostate, lung, breast and colon. In the liver, toxic compounds are bound to glucuronic
acids so that they can be eliminated in a safe form from the body in a cleansing process known as glucuronidation.
Beta-glucuronidase is a naturally occurring enzyme found in various organs and cells, which can cleave
apart these neutral compounds. Studies have indicated that d-glucarate moderates beta-glucurondiase enzyme
activity, supporting the process by which healthy cells eliminate waste and foreign elements. Other studies
suggest the promising role of d-glucarate in supporting healthy lipid metabolism.*
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| Methylsulfonylmethane (MSM): |
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Supplies a concentrated bioavailable source of elemental sulfur, an essential phase II enzyme detoxification
cofactor, as well as an essential micronutrient vital for healthy tissues.*
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| Folic Acid: |
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Integral factor involved in the formation of nucleic acids and the production of healthy DNA and chromosomes.
In particular, this B vitamin is critical for the proper neural and cellular development of the fetal central nervous system.
Folic acid romotes healthy cellular differentiation during the formation of the brain and spinal cord, helping to prevent
neural tube defects. Additionally, folic acid is important for the growth and reproduction of red and white blood cells.
Folic acid helps to support healthy homocysteine metabolism.*
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Recommendations
Helion Nutraceuticals recommends (for adults): 3 to 9 capusules daily, in divided doses.
Maintenance: 1 capsule, 3 times a day.
Therapeutic: 4 capsules, 3 times a day.
Three vegetable capsules contain: |
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| Alpha Lipoic Acid | 250 mg |
| N-Acetyl-Cystiene | 400 mg |
| Glycine | 1000 mg |
| Magnesim Glycinate | 125 mg |
| Malic Acid | 100 mg |
| Calcium D-glucarate | 100 mg |
| MSM | 75 mg |
| Folic Acid | 400 mcg |
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References
1Abou-Issa H et al. Relative efficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis. Anticancer Res 1995 May- Jun;15(3):805-10.
2Walaszek Z, Hanausek M, Sherman U, Adams AK. Antiproliferative effect of dietary glucarate on the Sprague-Dawley rat mammary gland. Cancer Lett 1990 Jan;49(1):51-7.
3Walaszek Z, Hanausek-Walaszek M, Minton JP, Webb TE. Dietary glucarate as anti-promoter of 7,12-dimethylbenz[a]anthracene- induced mammary tumorigenesis. Carcinogenesis
1986 Sep;7(9):1463-6.
4Walaszek Z, Hanausek-Walaszek M, Webb TE. Dietary glucarate-mediated reduction of sensitivity of murine strains to chemical carcinogenesis. Cancer Lett 1986 Oct;33(1):25-32.
5Oredipe OA, Barth RF, Dwivedi C, Webb TE. Chemopreventative activity of dietary glucarate on azoxymethane-induced altered hepatic foci in rats. Res Commun Chem Pathol
Pharmacol 1989 Sep;65(3):345-59.
6Webb TE, Pham-Nguyen MH, Darby M, Hamme AT. Pharmacokinetics relevant to the anti-carcinogenic and anti-tumor activities of glucarate and the synergistic combination of glucarate:
retinoid in the rat. Biochem Pharmacol1994 Apr 29;47(9):1655-60.
7Ballatori N, Lieberman MW, Wang W. N-acetylcysteine as an antidote in methylmercury poisoning. Environ Health Perspect 1998 May;106(5):267-71.
8Sumathi R, Baskaran G, Varalakshmi P. Relationship between glutathione and DL alpha-lipoic acid against cadmium-induced Hepatotoxicity. Jpn J Med Sci Biol 1996 Apr;
49(2):39-48.
9Deters M, Siegers CP, Strubelt O. Influence of glycine on the damage induced in isolated perfused rat liver by five hepatotoxic agents. Toxicology 1998 Jun 26;128(1):63-72.
10Shaikh ZA, Tang W. Protection against chronic cadmium toxicity by glycine. Toxicology 1999 Feb 15;132(2-3):139-46.
11Matilla B, Mauriz JL, Culebras JM, Gonzalez-Gallego J, Gonzalez P. Glycine: a cell-protecting anti-oxidant nutrient. Nutr Hosp 2002 Jan-Feb;17(1):2-9.
12Yin M, Ikejima K, Arteel GE, Seabra V, Bradford BU, Kono H, Rusyn I, Thurman RG. Glycine accelerates recovery from alcohol-induced liver injury. J Pharmacol Exp Ther 1998
Aug;286(2):1014-9.
13MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991 Jul 20;338(8760):131-137.
14Morrison HI, Schaubel D, Desmeules M, Wigle DT. Serum folate and risk of fatal coronary heart disease. JAMA 1996 Jun 26;275(24):1893-1896.
15Van Allen MI, Fraser FC, Dallaire L, Allanson J, McLeod DR, Andermann E, Friedman JM. Recommendations on the use of folic acid supplementation to prevent the recurrence
of neural tube defects. CMAJ 1993 Nov 1;149(9):1239-43.
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