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Features Include |
| Glucosamine Sulfate: |
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Glucosamine Sulfate works by stimulating the production of a very important structure in your cartilage called
the Glycosamine Glycans (GAG). Your GAG acts as a nutrient base for the growth of your cartilage. Stimulating this
complex will increase the production of your cartilage over time.*
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| Chondroitin Sulfate: |
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Chondroitin sulfate is part of a large protein molecule (proteoglycan) that gives cartilage elasticity.*
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| Methylsulfonylmethane: |
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MSM is a naturally occurring, sulfur-containing organic compound and provides 34% elemental sulfur, a compound
that is crucial in maintaining healthy tissues. Sulfur is a key nutrient needed to maintain connective tissue health, particularly those containing significant amounts of collagen and keratin, such as cartilage, skin, and nails.*
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| Hyaluronic acid: |
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Hyaluronic acid is a naturally occurring polymer found in every tissue of the body. It is particularly concentrated
in the skin and synovial fluid. It is composed of alternating units of n-acetyl-d-glucosamine and d-glucuronate.
This polymer's functions include attracting and retaining water in the extracellular matrix of tissues, and in synovial
fluid. For joints, HA is especially supportive of healthy lubrication and shock absorption. Furthermore, in vitro studies indicate that HA modulates prostaglandin production, providing additional support for joint function.*
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| Cetyl Myristoleate: |
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Cetyl Myristoleate (cis-9-cetyl myristoleate or CMO) is the ester of the fatty acid myristoleic acid. Our CMO
is the same form of CMO identified by the original discoverer, Dr. Diehl, and is patented for promoting joint function and comfort. In a 1994 study published in the Journal of Pharmaceutical Sciences, Dr. Diehl revealed
the joint support potential of this unique compound. This trial also suggested that the physiological activity
of CMO was not matched by other related fatty acids. A multi-center, double blind, randomized trial indicated that CMO and a CMO-containing formula promoted joint comfort compared to placebo. Proposed mechanisms of action for CMO include maintaining a healthy immune response at the cellular level and promoting joint lubrication.*
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| Lipase: |
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Lipases has a roles in the metabolism, absorption and transport of lipids throughout the body. Lipases are involved
in diverse biological processes ranging from routine metabolism of cell signaling and inflammation.*
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| Protease 6.0: |
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Protease 6.0 is a mixture of acid, neutral and alkaline proteases that demonstrates both exo-peptidase
and endo-peptidase activity with high substrate specificity. Protease 6.0 works synergistically with endogenous
enzymes by blocking some proinflammatory metabolites that accelerate and worsen the inflammatory process.
It is an anti-inflammatory agent, and so can be used for sports injury, trauma, arthritis, and other kinds of swelling.*
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Recommendations
Helion Nutraceuticals recommends (for adults):
3 to 9 capusules daily, in divided doses.
Three vegetable capsules contain: |
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| Glucosamine Sulfate | 1000 mg |
| Chondroitin Sulfate | 500 mg |
| Methylsulfonylmethane | 500 mg |
| Hyaluronic acid | 50 mg |
| Cetyl Myristoleate (20%) | 250 mg |
| Lipase | 300 mg |
| Protease 6.0 | 12000 HUT |
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References
1Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre JE, Gossett C. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet 2001 Jan 27;357(9252):251-6.
2Murav?ev IuV, Venikova MS, Pleskovskaia GN, Riazantseva TA, Sigidin IaA. Effect of dimethyl sulfoxide and dimethyl sulfone on a destructive process in the joints of mice
with spontaneous arthritis. Patol Fiziol Eksp Ter 1991 Mar;2:37-39.
3Murav?ev IV. Treatment of rheumatoid synovitis by intra-articular administration of dimethyl sulfoxide and corticosteroids. Ter Arkh 1986;58(7):104-5.
4Diehl HW, May EL. Cetyl myristoleate isolated from Swiss albino mice: an apparent protective agent against adjuvant arthritis in rats. J Pharm Sci 1994 ar;83(3):296-9.
5Siemandi H. The effect of cis-9-cetyl myristoleate (CMO) and adjunctive therapy on arthritis and auto-immune disease: a randomized trial. Townsend Letter for doctors and Patients 1997;Aug/Sept:58?63.
6Barrager E, Veltmann JR Jr, Schauss AG, Schiller RN. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J Altern Complement Med 2002 Apr;8(2):167-73.
7Greco RM, Iocono JA, Ehrlich HP. Hyaluronic acid stimulates human fibroblast proliferation within a collagen matrix. J Cell Physiol. 1998 Dec;177(3):465-73.
8Diehl HW, May EL. Cetyl myristoleate isolated from Swiss albino mice: an apparent protective agent against adjuvant arthritis in rats. J Pharm Sci. 1994 Mar;83(3):296-9.
9Hunter KW Jr. et al. Synthesis of cetyl myristoleate and evaluation of its therapeutic efficacy in a murine model of collagen-induced arthritis. Pharm Res. 2003 Jan;47(1):43-7.
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