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VitD3

 

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Vitamin D3 as Cholecalciferol:
CoQMend

Vitamin D3 enhances calcium absorption and retention, a key nutritional role in supporting healthy bones, and may play a potential role in cardiovascular, colon and cellular health. Vitamin D levels have been shown to decline with age, due primarily to a reduction in either absorption or metabolism by the liver. Decreased exposure to sunlight or a vegetarian diet play a role in inadequate vitamin D levels.*

Bone Health:
Vitamin D promotes intestinal calcium and phosphorous absorption and reduces urinary calcium loss, essential mechanisms for maintaining proper calcium levels in the body and for healthy bone composition. Clinical studies involving vitamin D supplementation suggest the importance of vitamin D in addition to calcium for bone health. Vitamin D supplementation alone may also support bone health.*

Cellular Health:
Studies suggest vitamin D supports colon health by promoting healthy cellular function. Vitamin D is also believed to provide general cellular support potential, including breast and prostate cells, in part by helping to maintain healthy angiogenesis balance, supporting immune cell activity and maintaining healthy cell metabolism. Preliminary evidence suggests that vitamin D may also play a role in maintaining healthy glucose metabolism, since vitamin D receptors are present on the islet cells of the pancreas.*

 
Inulin:

Inulin is a type of dietary fiber that is naturally found in hundreds of common foods such as leeks, artichokes, asparagus, onions, garlic, bananas, wheat, rye, and chicory root. Inulin fiber is a carbohydrate belonging to a class of compounds known as fructans. Because inulin fiber is resistant to digestion in the upper gastrointestional tract it reaches the large intestine essentially intact, where it is fermented by indigenous bacteria.

Inulin fiber naturally occurs as a series of oligo- and polysaccharides with different chain lengths. Inulin fiber is not absorbed from the gastrointestinal system. Perhaps the best-known nutritional effects of inulin and oligofructose are their actions to stimulate bifidobacteria growth in the intestine. Preliminary studies suggest that adding inulin to calcium-rich foods like yogurt may boost calcium absorption.

Soluble and insoluble fibers both contribute to gastrointestinal health, albeit in different ways. Insoluble fibers contribute to gastrointestinal health by promoting regularity and peristalsis, yet a soluble fiber such as inulin boasts a somewhat wider range of benefits. Unlike their insoluble counterparts, soluble fibers are fermentable and their contribution to gastrointestinal health consists largely of the by-products of this fermentation, including short chain fatty acids (SCFA's) such as butyric and propionic acid. These in turn help regulate glucose metabolism, lower plasma cholesterol levels, stimulate the immune system, and of course promote the growth of beneficial gastrointestinal flora. Inulin also boasts one of the lowest glycemic indexes (GI) of any carbohydrate source and can also improve the absorption of the essential mineral calcium.

 
Calcium and Iron Absorption:

Since it has been established that inulin's prebiotic capability results in the overall improved state of the gastrointestinal system, it stands to reason that such an improvement can encompass the villus. Simply put, the villus is the vast complex that lines the entire length of the intestine and is responsible for absorbing the nutrients from the food we eat. One of the essential nutrients is the mineral calcium, and inulin has indeed been studied for its ability to increase calcium absorption. One placebo-controlled study conducted among 59 young girls (at or near menarche) found that inulin supplementation increased calcium absorption by more than 15%. Another study conducted among 9 healthy adults (average age: 25.5 years) found that inulin supplementation increased the absorption of calcium by 58%. Finally, in another randomized, double-blind study - this one conducted among postmenopausal female subjects (the highest risk group for osteoporosis) - inulin supplementation increased calcium absorption by 16%.



Recommendations

Helion Nutraceuticals recommends (for adults):
1 to 3 capsules daily, in divided doses.

One vegetable capsule contains:

Vitamin D3 (Cholecalciferol) 5000 IU
Inulin 375 mg


References

1Kantorovich V, Gacad MA, Seeger LL, Adams JS. Bone mineral density increases with vitamin D repletion in patients with coexistent vitamin D insufficiency and primary hyperparathyroidism. J Clin Endocrinol Metab. 2000 Oct;85(10):3541-3.
2Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997 Sep 4;337(10):670-6.
3Vogelsang H, Ferenci P, Resch H, Kiss A, Gangl A. Prevention of bone mineral loss in patients with Crohn?s disease by long-term oral vitamin D supplementation. Eur J Gastroenterol Hepatol. 1995 Jul;7(7):609-14.
4Lind L, Wengle B, Wide L, Ljunghall S. Reduction of blood pressure during long-term treatment with active vitamin D (alphacalcidol) is dependent on plasma renin activity and calcium status. A double-blind, placebo-controlled study. Am J Hypertens. 1989 Jan;2(1):20-5.
5Labriji-Mestaghanmi H, Billaudel B, Garnier PE, Malaisse WJ, Sutter BC.Vitamin D and pancreatic islet function. I. Time course for changes in insulin secretion and content during vitamin D deprivation and repletion. J Endocrinol Invest. 1988 Sep;11(8): 577-84.
6Wilkins CH, Sheline YI, Roe CM, Birge SJ, Morris JC. Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry. 2006 Dec;14(12):1032-40.
7Bouhnik Y., Flourié B., Ouarne F., Riottot M., Bisetti N, Bornet F., Rambaud J. Effects of prolonged ingestion of fructo-oligosaccharides on colonic bifidobacteria, fecal enzymes and bile acids in humans. Gastroenterology 1994;106:A598(abs.)
8Coudray C., Bellanger J., Castiglia-Delavaud C., Rémésy C., Vermorel M., Rayssignuier Y. Effect of soluble or partly soluble dietary fibers supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men. Eur. J. Clin. Nutr. 1997;51:375-380.

 

 

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* This is a statement of nutritional support. This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. For educational purposes only. Consult your physician for any health problems.

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